Susceptibility of the elderly to SARS-CoV-2 infection: ACE-2 overexpression, shedding, and antibody-dependent enhancement (ADE)

JPS Peron, H Nakaya - Clinics, 2020 - SciELO Brasil
The world is currently facing a serious SARS-CoV-2 infection pandemic. This virus is a new
isolate of coronavirus, and the current infection crisis has surpassed the SARS and MERS …

COVID‐19 is an emergent disease of aging

D Santesmasses, JP Castro, AA Zenin… - Aging cell, 2020 - Wiley Online Library
COVID‐19 is an ongoing pandemic caused by the SARS‐CoV‐2 coronavirus that poses one
of the greatest challenges to public health in recent years. SARS‐CoV‐2 is known to …

The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions

T Behl, I Kaur, S Bungau, A Kumar, MS Uddin, C Kumar… - Life Sciences, 2020 - Elsevier
The novel corona virus disease has shaken the entire world with its deadly effects and rapid
transmission rates, posing a significant challenge to the healthcare authorities to develop …

Is Covid-19 severity associated with ACE2 degradation?

U Bastolla, P Chambers, D Abia… - Frontiers in Drug …, 2022 - frontiersin.org
Covid-19 is particularly mild with children, and its severity escalates with age. Several
theories have been proposed to explain these facts. In particular, it was proposed that the …

[HTML][HTML] SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications

S Gross, C Jahn, S Cushman, C Baer… - Journal of molecular and …, 2020 - Elsevier
The current COVID-19 pandemic started several months ago and is still exponentially
growing in most parts of the world–this is the most recent and alarming update. COVID-19 …

Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation

J Chen, Q Jiang, X Xia, K Liu, Z Yu, W Tao, W Gong… - Aging cell, 2020 - Wiley Online Library
The COVID‐19 coronavirus is now spreading worldwide. Its pathogen, SARS‐CoV‐2, has
been shown to use angiotensin‐converting enzyme 2 (ACE2) as its host cell receptor, same …

The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review

R Rodrigues, S Costa de Oliveira - Microorganisms, 2021 - mdpi.com
Angiotensin-Converting Enzyme 2 (ACE2) has been proved to be the main host cell receptor
for the binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the …

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

MY Li, L Li, Y Zhang, XS Wang - Infectious diseases of poverty, 2020 - mednexus.org
Background: Since its discovery in December 2019, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has infected more than 2 180 000 people worldwide and has …

[HTML][HTML] COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches

F Moccia, A Gerbino, V Lionetti, M Miragoli… - Geroscience, 2020 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells following
binding with the cell surface ACE2 receptors, thereby leading to coronavirus disease 2019 …

Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19

G Li, X He, L Zhang, Q Ran, J Wang, A Xiong… - Journal of …, 2020 - Elsevier
It has been reported that SARS-CoV-2 may use ACE2 as a receptor to gain entry into human
cells, in a way similar to that of SARS-CoV. Analyzing the distribution and expression level of …