Probing the architecture, mechanism, and dynamics of genome folding is fundamental to our
understanding of genome function in homeostasis and disease. Most chromosome …

The relationship between the 4D folding of the genome and its function is an outstanding
question in biology. A range of methods that probe the folding of the genome in space and …

The spatial architecture and dynamics of the genomic material in the limited volume of the
nucleus plays an important role in biological processes ranging from gene expression to …

New technological advances in integrated imaging, sequencing-based assays, and
computational analysis have revolutionized our view of genomes in terms of their structure …

Over the last decades, technological breakthroughs in super-resolution microscopy have
allowed us to reach molecular resolution and design experiments of unprecedented …

The mammalian genome is complex and presents a dynamic structural organization that
reflects function. Organization of the genome inside the mammalian nucleus impacts all …

Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …

The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …

The 3D organization of chromatin regulates many genome functions. Our understanding of
3D genome organization requires tools to directly visualize chromatin conformation in its …

The three-dimensional architecture of the genome affects genomic functions. Multiple
genome architectures at different length scales, including chromatin loops, domains …