[HTML][HTML] An epigenetic aging clock for dogs and wolves

MJ Thompson, S Horvath, M Pellegrini - Aging (Albany NY), 2017 - ncbi.nlm.nih.gov
Several articles describe highly accurate age estimation methods based on human DNA-
methylation data. It is not yet known whether similar epigenetic aging clocks can be …

DNA methylation clocks for dogs and humans

S Horvath, AT Lu, A Haghani… - Proceedings of the …, 2022 - National Acad Sciences
DNA methylation profiles have been used to develop biomarkers of aging known as
epigenetic clocks, which predict chronological age with remarkable accuracy and show …

Epigenetic clock and methylation studies in cats

K Raj, B Szladovits, A Haghani, JA Zoller, CZ Li… - GeroScience, 2021 - Springer
Human DNA methylation profiles have been used successfully to develop highly accurate
biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not …

Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species

R Lowe, C Barton, CA Jenkins, C Ernst, O Forman… - Genome biology, 2018 - Springer
Background Mammalian species exhibit a wide range of lifespans. To date, a robust and
dynamic molecular readout of these lifespan differences has not yet been identified. Recent …

Multi-tissue DNA methylation age predictor in mouse

TM Stubbs, MJ Bonder, AK Stark, F Krueger… - Genome biology, 2017 - Springer
Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …

Estimation of chimpanzee age based on DNA methylation

H Ito, T Udono, S Hirata, M Inoue-Murayama - Scientific Reports, 2018 - nature.com
In wild animal conservation, knowing the age of an individual animal is extremely beneficial.
However, estimating the age is difficult for many species. Recently, epigenetics-based …

Measuring animal age with DNA methylation: From humans to wild animals

R De Paoli-Iseppi, BE Deagle, CR McMahon… - Frontiers in …, 2017 - frontiersin.org
DNA methylation (DNAm) is a key mechanism for regulating gene expression in animals
and levels are known to change with age. Recent studies have used DNAm changes as a …

Age estimation using methylation-sensitive high-resolution melting (MS-HRM) in both healthy felines and those with chronic kidney disease

H Qi, K Kinoshita, T Mori, K Matsumoto, Y Matsui… - Scientific Reports, 2021 - nature.com
Age is an important ecological tool in wildlife conservation. However, it is difficult to estimate
in most animals, including felines—most of whom are endangered. Here, we developed the …

Epigenetic clock and methylation studies in elephants

NA Prado, JL Brown, JA Zoller, A Haghani, M Yao… - Aging cell, 2021 - Wiley Online Library
Age‐associated DNA‐methylation profiles have been used successfully to develop highly
accurate biomarkers of age (" epigenetic clocks") in humans, mice, dogs, and other species …

Multi-tissue DNA methylation aging clocks for sea lions, walruses and seals

TR Robeck, A Haghani, Z Fei, DM Lindemann… - Communications …, 2023 - nature.com
Age determination of wild animals, including pinnipeds, is critical for accurate population
assessment and management. For most pinnipeds, current age estimation methodologies …