JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.
T Kallunki, B Su, I Tsigelny, HK Sluss… - Genes & …, 1994 - genesdev.cshlp.org
The transcriptional activity of c-Jun is augmented through phosphorylation at two sites by a c-
Jun amino-terminal kinase (JNK). All cells express two distinct JNK activities, 46 and 55 kD …
Jun amino-terminal kinase (JNK). All cells express two distinct JNK activities, 46 and 55 kD …
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases
A Minden, A Lin, T Smeal, B Dérijard… - … and cellular biology, 1994 - Am Soc Microbiol
Abstract c-Jun transcriptional activity is stimulated by phosphorylation at two N-terminal
sites: Ser-63 and-73. Phosphorylation of these sites is enhanced in response to a variety of …
sites: Ser-63 and-73. Phosphorylation of these sites is enhanced in response to a variety of …
Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
M Hibi, A Lin, T Smeal, A Minden… - Genes & …, 1993 - genesdev.cshlp.org
The activity of c-Jun is regulated by phosphorylation. Various stimuli including transforming
oncogenes and UV light, induce phosphorylation of serines 63 and 73 in the amino-terminal …
oncogenes and UV light, induce phosphorylation of serines 63 and 73 in the amino-terminal …
[HTML][HTML] The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity
C Zheng, J Xiang, T Hunter, A Lin - Journal of Biological Chemistry, 1999 - ASBMB
c-Jun N-terminal protein kinase (JNK), a member of the mitogen-activated protein (MAP)
kinase family, regulates gene expression in response to various extracellular stimuli. JNK is …
kinase family, regulates gene expression in response to various extracellular stimuli. JNK is …
Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor
C Dunn, C Wiltshire, A MacLaren, DAF Gillespie - Cellular signalling, 2002 - Elsevier
The regulation of c-Jun transcriptional activity by Jun N-terminal kinase (JNK) has become a
paradigm for understanding how mitogen-activated protein (MAP) kinase signalling …
paradigm for understanding how mitogen-activated protein (MAP) kinase signalling …
[HTML][HTML] JNK2 is a positive regulator of the cJun transcription factor
A Jaeschke, M Karasarides, JJ Ventura, A Ehrhardt… - Molecular cell, 2006 - cell.com
The cJun NH 2-terminal kinase (JNK) signal transduction pathway is established to be an
important mechanism of regulation of the cJun transcription factor. Studies of Jnk1−/− and …
important mechanism of regulation of the cJun transcription factor. Studies of Jnk1−/− and …
[HTML][HTML] Regulation and function of the JNK subgroup of MAP kinases
A Minden, M Karin - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1997 - Elsevier
Mammalian cells respond to extracellular stimuli by activating signaling cascades that are
mediated by members of the MAP kinase family. MAP kinases act by phosphorylating …
mediated by members of the MAP kinase family. MAP kinases act by phosphorylating …
Signal transduction by the c-Jun N-terminal kinase
RJ Davis - Biochemical Society Symposia, 1999 - degruyter.com
The c-Jun N-terminal kinase (JNK) group of mitogen-activated protein kinases (MAP
kinases) is activated by exposure of cells to environmental stress and by the treatment of …
kinases) is activated by exposure of cells to environmental stress and by the treatment of …
The MKK7 Gene Encodes a Group of c-Jun NH2-Terminal Kinase Kinases
C Tournier, AJ Whitmarsh, J Cavanagh… - … and cellular biology, 1999 - Taylor & Francis
The c-Jun NH2-terminal protein kinase (JNK) is a member of the mitogen-activated protein
kinase (MAPK) group and is an essential component of a signaling cascade that is activated …
kinase (MAPK) group and is an essential component of a signaling cascade that is activated …
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif
The DNA-dependent protein kinase (DNA-PK) phosphorylates a number of transcription
factors. Here, we show that the DNA-PK modifies c-Jun in vitro and that serlne residue 249 …
factors. Here, we show that the DNA-PK modifies c-Jun in vitro and that serlne residue 249 …