Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients
A global effort is currently undertaken to restrain the COVID-19 pandemic. Host immunity
has come out as a determinant for COVID-19 clinical outcomes, and several studies …
has come out as a determinant for COVID-19 clinical outcomes, and several studies …
The COVID-19 pandemic: does our early life environment, life trajectory and socioeconomic status determine disease susceptibility and severity?
C Holuka, MP Merz, SB Fernandes… - International journal of …, 2020 - mdpi.com
A poor socioeconomic environment and social adversity are fundamental determinants of
human life span, well-being and health. Previous influenza pandemics showed that …
human life span, well-being and health. Previous influenza pandemics showed that …
SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes
J Nikolich-Zugich, KS Knox, CT Rios, B Natt… - Geroscience, 2020 - Springer
Abstract SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19
(COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over …
(COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over …
The lethal sex gap: COVID-19
Abstract While Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is disrupting lives across the globe for everyone, it …
syndrome coronavirus 2 (SARS-CoV-2), is disrupting lives across the globe for everyone, it …
Age-related changes in plasma biomarkers and their association with mortality in COVID-19
EHA Michels, B Appelman… - European …, 2023 - Eur Respiratory Soc
Background Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly
in older patients. Several immunomodulating therapies seem less beneficial in these …
in older patients. Several immunomodulating therapies seem less beneficial in these …
Elderly at time of COronaVIrus disease 2019 (COVID-19): possible role of immunosenescence and malnutrition
L Bencivenga, G Rengo, G Varricchi - Geroscience, 2020 - Springer
The unprecedented COVID-19 pandemic is rapidly and unpredictably evolving and the
majority of deaths are occurring in older people. A partial description of the magnitude of the …
majority of deaths are occurring in older people. A partial description of the magnitude of the …
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”
Abstract Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
[HTML][HTML] Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections
A Zhavoronkov - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
The recently identified SARS-CoV-2 betacoronavirus responsible for the COVID-19
pandemic has uncovered the age-associated vulnerability in the burden of disease and put …
pandemic has uncovered the age-associated vulnerability in the burden of disease and put …
Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral …
K Evangelou, D Veroutis, K Paschalaki… - European …, 2022 - Eur Respiratory Soc
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of
the respiratory system can progress to a multisystemic disease with aberrant inflammatory …
the respiratory system can progress to a multisystemic disease with aberrant inflammatory …
[HTML][HTML] Senolytics and senostatics: a two-pronged approach to target cellular senescence for delaying aging and age-related diseases
C Kang - Molecules and cells, 2019 - Elsevier
Aging is the most important single risk factor for many chronic diseases such as cancer,
metabolic syndrome, and neurodegenerative disorders. Targeting aging itself might …
metabolic syndrome, and neurodegenerative disorders. Targeting aging itself might …