The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in
vitro,,,–, but their developmental potential is substantially extended by interactions with …

Implantation of the human embryo begins a critical developmental stage that comprises
profound events including axis formation, gastrulation and the emergence of haematopoietic …

INTRODUCTION Early mammalian development requires the formation of embryonic and
extraembryonic tissues and a highly coordinated partnership between them. This close …

The mammalian body plan is established shortly after the embryo implants into the maternal
uterus, and our understanding of post-implantation developmental processes remains …

In vitro cultured stem cells with distinct developmental capacities can contribute to
embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian …

Embryonic stem cells can be incorporated into the developing embryo and its germ line, but,
when cultured alone, their ability to generate embryonic structures is restricted. They can …

Our knowledge of the molecular mechanisms surrounding human embryo implantation and
gastrulation is lacking, largely due to technical and ethical limitations of experimenting with …

The difficulty of studying post-implantation development in mammals has sparked a flurry of
activity to develop in vitro models, termed embryoids, based on self-organizing pluripotent …