Recent technological advances that allow faster and cheaper DNA sequencing are now
driving biological and medical research. In this review, we provide an overview of state-of …

Organismal aging is driven by interconnected molecular changes encompassing internal
and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets …

Aging is a ubiquitous biological process that limits the maximal lifespan of most organisms.
Significant efforts by many groups have identified mechanisms that, when triggered by …

Diverse individuals age at different rates and display variable susceptibilities to tissue aging,
functional decline and aging-related diseases. Centenarians, exemplifying extreme …

Genome-wide sequencing has enabled modern biomedical research to relate more and
more events in healthy as well as disease-affected cells and tissues to the genomic …

Aging is a complex process that accompanied by molecular and cellular alterations. The
identification of tissue-/cell type-specific biomarkers of aging and elucidation of the detailed …

The recent development of microarray technology provided unprecedented opportunities to
understand the genetic basis of aging. So far, many microarray studies have addressed …

The 40 th anniversary of Cell coincides with that of the National Institute on Aging (NIA).
Indeed, Cell papers on NIA-funded research helped move the field into a genetic and …

Motivation: Numerous microarray studies of aging have been conducted, yet given the noisy
nature of gene expression changes with age, elucidating the transcriptional features of …

High-throughput genomic and proteomic technologies have generated a wealth of publicly
available data on ageing. Easy access to these data, and their computational analysis, is of …