AD Roses - Annals of the New York Academy of Sciences, 1998 - Wiley Online Library
Apolipoprotein E (APOE) is a true susceptibility polymorphism of the common form of Alzheimer's disease (AD). There are three APOE alleles (ɛ2, ɛ3, ɛ4) that are universally …
DJ Selkoe - Neurologic clinics, 2000 - neurologic.theclinics.com
Few experiences in the work of a neurologic diagnostician are more disquieting than informing both patient and family that the diagnosis is Alzheimer's disease (AD). Yet, with the …
A Tandon, E Rogaeva, M Mullan… - Current Opinion in …, 2000 - journals.lww.com
Alzheimer's disease is the most common neurodegenerative disorder of aging, accounting for an estimated two-thirds of all cases of senile dementia. Epidemiologic studies have failed …
JWPF Kardaun, L White, HE Resnick… - Clinical …, 2000 - academic.oup.com
Background: The utility of apolipoprotein E (ApoE) type as an indicator of genetic susceptibility to Alzheimer disease (AD) depends on the reliability of typing. Although ApoE …
Article abstract-Inheritance of the apolipoprotein E (APOE= gene; apoE= protein) epsilon 4 gene is associated with a higher risk for development of Alzheimer's disease (AD) and for …
AD Roses, MD - Annual review of medicine, 1996 - annualreviews.org
▪ Abstract Alzheimer's disease (AD) is unique in medicine in that millions of people suffer from what appears to be the same form of disease, and unlike most other late-onset …
BT Hyman, T Gomez-Isla… - Annals of the New …, 1996 - pubmed.ncbi.nlm.nih.gov
Our studies of the APOE genotype in AD confirm a strong association of the epsilon 4 allele with development of AD and a decreased risk associated with epsilon 2. From a clinical …
In order to quantify the effects of apolipoprotein (apo) E on early-and late-onset, sporadic and familial Alzheimer's disease (AD) more precisely we performed a meta-analysis of 42 …
Apolipoprotein E (APOE) polymorphisms are associated with variable risk and age of onset distributions for the common form of Alzheimer disease. Clinical genetic applications of …