Genetics and the dementia patient

LA Farrer - The Neurologist, 1997 - journals.lww.com
BACKGROUND: Alzheimer's disease (AD) is a common fatal neurodegenerative disorder for
which there is no effective treatment or cure. The biological basis of AD is poorly understood …

Apolipoprotein E and Alzheimer's disease: the tip of the susceptibility iceberg

AD Roses - Annals of the New York Academy of Sciences, 1998 - Wiley Online Library
Apolipoprotein E (APOE) is a true susceptibility polymorphism of the common form of
Alzheimer's disease (AD). There are three APOE alleles (ɛ2, ɛ3, ɛ4) that are universally …

The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins

DJ Selkoe - Neurologic clinics, 2000 - neurologic.theclinics.com
Few experiences in the work of a neurologic diagnostician are more disquieting than
informing both patient and family that the diagnosis is Alzheimer's disease (AD). Yet, with the …

Molecular genetics of Alzheimer's disease: the role of β-amyloid and the presenilins

A Tandon, E Rogaeva, M Mullan… - Current Opinion in …, 2000 - journals.lww.com
Alzheimer's disease is the most common neurodegenerative disorder of aging, accounting
for an estimated two-thirds of all cases of senile dementia. Epidemiologic studies have failed …

Genotypes and phenotypes for apolipoprotein E and Alzheimer disease in the Honolulu-Asia aging study

JWPF Kardaun, L White, HE Resnick… - Clinical …, 2000 - academic.oup.com
Background: The utility of apolipoprotein E (ApoE) type as an indicator of genetic
susceptibility to Alzheimer disease (AD) depends on the reliability of typing. Although ApoE …

Alzheimer's disease: clinical implications of the apolipoprotein E genotype

MR Farlow - Neurology, 1997 - AAN Enterprises
Article abstract-Inheritance of the apolipoprotein E (APOE= gene; apoE= protein) epsilon 4
gene is associated with a higher risk for development of Alzheimer's disease (AD) and for …

Apolipoprotein E alleles as risk factors in Alzheimer's disease

AD Roses, MD - Annual review of medicine, 1996 - annualreviews.org
▪ Abstract Alzheimer's disease (AD) is unique in medicine in that millions of people suffer
from what appears to be the same form of disease, and unlike most other late-onset …

Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease

BT Hyman, T Gomez-Isla… - Annals of the New …, 1996 - pubmed.ncbi.nlm.nih.gov
Our studies of the APOE genotype in AD confirm a strong association of the epsilon 4 allele
with development of AD and a decreased risk associated with epsilon 2. From a clinical …

Apolipoprotein E genetic variation and Alzheimer's disease: a meta-analysis

DC Rubinsztein, DF Easton - Dementia and geriatric cognitive disorders, 1999 - karger.com
In order to quantify the effects of apolipoprotein (apo) E on early-and late-onset, sporadic
and familial Alzheimer's disease (AD) more precisely we performed a meta-analysis of 42 …

A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer disease

AD Roses - Neurogenetics, 1997 - Springer
Apolipoprotein E (APOE) polymorphisms are associated with variable risk and age of onset
distributions for the common form of Alzheimer disease. Clinical genetic applications of …