[HTML][HTML] SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

U Tripathi, R Nchioua, LGPL Prata, Y Zhu… - Aging (albany …, 2021 - ncbi.nlm.nih.gov
Senescent cells, which arise due to damage-associated signals, are apoptosis-resistant and
can express a pro-inflammatory, tissue-destructive senescence-associated secretory …

[HTML][HTML] SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

S Tsuji, S Minami, R Hashimoto, Y Konishi, T Suzuki… - Nature aging, 2022 - nature.com
Reports of post-acute COVID-19 syndrome, in which the inflammatory response persists
even after SARS-CoV-2 has disappeared, are increasing, but the underlying mechanisms of …

[HTML][HTML] COVID-19 and cellular senescence

CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …

Senolytics reduce coronavirus-related mortality in old mice

CD Camell, MJ Yousefzadeh, Y Zhu, LGPL Prata… - Science, 2021 - science.org
INTRODUCTION The COVID-19 pandemic revealed enhanced vulnerability of the elderly
and chronically ill to adverse outcomes upon severe acute respiratory syndrome coronavirus …

[HTML][HTML] Virus-induced senescence is a driver and therapeutic target in COVID-19

S Lee, Y Yu, J Trimpert, F Benthani, M Mairhofer… - Nature, 2021 - nature.com
Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …

[HTML][HTML] Role of senescence in the chronic health consequences of COVID-19

EOW Gerdes, G Vanichkachorn, BP Verdoorn… - Translational …, 2022 - Elsevier
While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards
of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long …

[HTML][HTML] Role of senescence and aging in SARS-CoV-2 infection and COVID-19 disease

SM Lynch, G Guo, DS Gibson, AJ Bjourson, TS Rai - Cells, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic associated with substantial …

[HTML][HTML] Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral …

K Evangelou, D Veroutis, K Paschalaki… - European …, 2022 - Eur Respiratory Soc
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of
the respiratory system can progress to a multisystemic disease with aberrant inflammatory …

Treatment with the senolytics dasatinib/quercetin reduces SARS‐CoV‐2‐related mortality in mice

A Pastor‐Fernández, AR Bertos, A Sierra‐Ramírez… - Aging …, 2023 - Wiley Online Library
The enormous societal impact of the ongoing COVID‐19 pandemic has been particularly
harsh for some social groups, such as the elderly. Recently, it has been suggested that …

Cellular senescence as a potential mediator of COVID‐19 severity in the elderly

J Nehme, M Borghesan, S Mackedenski, TG Bird… - Aging cell, 2020 - Wiley Online Library
SARS‐CoV‐2 is a novel betacoronavirus which infects the lower respiratory tract and can
cause coronavirus disease 2019 (COVID‐19), a complex respiratory distress syndrome …