In the last 10 years significant progress has been made to describe and identify the
underlying biological mechanisms that cause the different manifestation of Alzheimer's …

At present it is not clear whether Alzheimer's disease is a single disease, a complex
syndrome, or a heterogeneous ill-defined group of disorders. In the last few years significant …

Application of genetic paradigms to Alzheimer's disease (AD) has led to confirmation that
genetic factors play a role in this disease. Additionally, researchers now understand that AD …

Late‐onset Alzheimer's disease (AD) is a complex and multifactorial disease with the
possible involvement of several genes. Apolipoprotein E (APOE), especially the APOE* 4 …

Inherited Alzheimer's disease is a genetically heterogeneous disorder that involves gene
defects on at least five chromosomal loci. Three of these loci have been found by genetic …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central
nervous system that is invariably associated with and defined by the presence of …

The genetic epidemiology of sporadic Alzheimer's disease (SAD) remains a very active area
of research, making it one of the most prolifically published areas in medicine and biology …

Alzheimer's disease is the most common neurodegenerative disorder of aging, accounting
for an estimated two-thirds of all cases of senile dementia. Epidemiologic studies have failed …

In early 1993, the genetic data implicating the amyloid precursor protein as one of the loci
leading to early onset Alzheimer's disease were reviewed (Hardy and Duff, Annals of …

This paper reexamines recent epidemiologic and molecular genetic studies on the genetic
basis of Alzheimer's Disease (AD). Careful analysis of the available epidemiologic data …