Epigenetic clocks, developed using DNA methylation data, have been widely used to
quantify biological aging in multiple tissues/cells. However, many existing epigenetic clocks …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Epigenetic clocks have come to be regarded as powerful tools for estimating aging.
However, a major drawback in their application is our lack of mechanistic understanding. We …

Human DNA-methylation data have been used to develop highly accurate biomarkers of
aging (" epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for …

Epigenetic alterations are a hallmark of aging and age‐related diseases. Computational
models using DNA methylation data can create “epigenetic clocks” which are proposed to …

It has been noted for quite some time that DNA methylation levels decline with age. The
significance of this change remained unknown until it became possible to measure …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

Robust biomarkers of aging have been developed from DNA methylation in humans and
more recently, in mice. This study aimed to generate a novel epigenetic clock in rats—a …

All humans age, but how we age—and how fast—differs considerably from person to
person. This deviation between apparent age and chronological age is often referred to as …