The last decade has seen an incredible breakthrough in technologies that allow histones,
transcription factors (TFs), and RNA polymerases to be precisely mapped throughout the …

Eukaryotic gene regulation involves a balance between packaging of the genome into
nucleosomes and enabling access to regulatory proteins and RNA polymerase …

Promoters and enhancers are key cis-regulatory elements, but how they operate to generate
cell type-specific transcriptomes is not fully understood. We developed a simple and robust …

An enormous body of work generated over the past three decades has revealed that
eukaryotic gene transcription is a remarkably intricate biochemical process that is tightly …

Eukaryotes employ combinatorial strategies to generate a variety of expression patterns
from a relatively small set of regulatory DNA elements. As in any other language …

Complex transcriptional behaviours are encoded in the DNA sequences of gene regulatory
regions. Advances in our understanding of these behaviours have been recently gained …

With the explosion of genome-wide studies of regulated transcription, it has become clear
that traditional definitions of enhancers and promoters need to be revisited. These control …

Transcription, or the process by which DNA produces RNA, is a central aspect of gene
expression. Transcription factors regulate transcription during development and in disease …

Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …

Enhancers establish spatial or temporal patterns of gene expression that are critical for
development, yet our understanding of how these DNA cis-regulatory elements function from …