Transcription, or the process by which DNA produces RNA, is a central aspect of gene
expression. Transcription factors regulate transcription during development and in disease …

Nearly 7 decades have elapsed since Francis Crick introduced the central dogma of
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …

Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

The ENCODE Project has generated a wealth of experimental information mapping diverse
chromatin properties in several human cell lines. Although each such data track is …

Regulated gene expression, achieved through the coordinated assembly of transcription
factors, co‐regulators and the basal transcription machinery on promoters, is an initial step …

The application of deep sequencing to map 5′ capped transcripts has confirmed the
existence of at least two distinct promoter classes in metazoans:“focused” promoters with …

Virtually all cell types have the same DNA, yet each type exhibits its own cell-specific pattern
of gene expression. During the brief period of mitosis, the chromosomes exhibit changes in …

The Mediator complex directs signals from DNA-binding transcription factors to RNA
polymerase II (Pol II). Despite this pivotal position, mechanistic understanding of Mediator in …

Chromatin remodeling complexes play essential roles in metazoan development through
widespread control of gene expression, but the precise molecular mechanisms by which …