Higher-order chromosomal organization for transcription regulation is poorly understood in
eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag …

The genome must be highly compacted to fit within eukaryotic nuclei but must be accessible
to the transcriptional machinery to allow appropriate expression of genes in different cell …

Gene expression is regulated at multiple levels, and cells need to integrate and coordinate
different layers of control to implement the information in the genome. Post-transcriptional …

Information about developmental gene expression resides in defined regulatory elements,
called enhancers, in the non-coding part of the genome. Although cells reliably utilize …

Enhancers, silencer and insulators are DNA elements that play central roles in regulation of
the genome that are crucial for development and differentiation. In metazoans, these …

Cellular functions including transcription regulation, DNA repair, and DNA replication need
to be tightly regulated. DNA sequence can contribute to the regulation of these mechanisms …

Gene expression during development and differentiation is regulated in a cell-and stage-
specific manner by complex networks of intergenic and intragenic cis-regulatory elements …

Among the diverse transcription factors that are necessary to elicit changes in cell fate, both
in embryonic development and in cellular reprogramming, a subset of factors are capable of …

It is a truth (almost) universally acknowledged that conserved non-coding genomic
sequences function in the cis regulation of neighbouring genes. But is this a misconception …

Transcriptional regulation is achieved through combinatorial interactions between regulatory
elements in the human genome and a vast range of factors that modulate the recruitment …