Cellular senescence can modulate various pathologies and is associated with irreparable
DNA double-strand breaks (IrrDSBs). Extracellular senescence metabolomes (ESMs) were …

Calorie restriction (CR) extends life span and ameliorates age-related pathologies in most
species studied, yet the mechanisms underlying these effects remain unclear. Using mouse …

Stem cells are imbued with unique qualities. They have the capacity to propagate
themselves through symmetric divisions and to divide asymmetrically to engender new cells …

Mouse-sized naked mole-rats (Heterocephalus glaber), unlike other mammals, do not
conform to Gompertzian laws of age-related mortality; adults show no age-related change in …

Stem cells are required for lifelong homeostasis and regeneration of tissues and organs in
mammals, but the function of stem cells declines during aging. To preserve stem cells during …

Nucleotide synthesis is essential to proliferating cells, but the preferred precursors for de
novo biosynthesis are not defined in human cancer tissues. We have employed multiplexed …

Developing methods for accurate detection of RNA modifications remains a major challenge
in epitranscriptomics. Next-generation sequencing-based mapping approaches have …

Adenocarcinoma, a type of non–small cell lung cancer, is the most frequently diagnosed
lung cancer and the leading cause of lung cancer mortality in the United States. It is well …

Stimulating regeneration of complex tissues and organs after injury to effect complete
structural and functional repair, is an attractive therapeutic option that would revolutionize …

The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can
convert somatic differentiated cells into pluripotent stem cells in a process known as …