Recent advances in our understanding of tissue regeneration and the development of
efficient approaches to induce and differentiate pluripotent stem cells for cell replacement …

Metabolism plays a central role in virtually all diseases, including diabetes, cancer, and
neurodegeneration. Detailed analysis is required to identify the specific metabolic pathways …

Metabolites, the chemical entities that are transformed during metabolism, provide a
functional readout of cellular biochemistry. With emerging technologies in mass …

Here we review the environmental and genetic manipulations that link cellular and
organismal metabolism to aging. In particular, we explore how nutrients are sensed and how …

Abstract System-wide metabolic homeostasis is crucial for maintaining physiological
functions of living organisms. Stable-isotope tracing metabolomics allows to unravel …

Metabolism is influenced by age, food intake, and conditions such as diabetes and obesity.
How do physiological or pathological metabolic changes influence stem cells, which are …

Individual cells are basic units of life. Despite extensive efforts to characterize the cellular
heterogeneity of different organisms, cross-species comparisons of landscape dynamics …

Aging is associated with distinct phenotypical, physiological, and functional changes,
leading to disease and death. The progression of aging-related traits varies widely among …

Biological diversity among mammals is remarkable. Mammalian body weights range seven
orders of magnitude and lifespans differ more than 100-fold among species. While genetic …

Age-associated chronic inflammation (inflammageing) is a central hallmark of ageing, but its
influence on specific cells remains largely unknown. Fibroblasts are present in most tissues …