Recent breakthroughs in cancer metabolism include the identification of an alternative
glycolytic pathway in proliferative cells and an essential role for the serine synthesis …

Cancer is a disease of uncontrolled cell growth and a major cause of death worldwide. Many
molecular events characterize tumor initiation and progression. Global gene expression …

Cancer metabolism has emerged as an indispensable part of contemporary cancer
research. During the past 10 years, the use of stable isotopic tracers and network analysis …

Despite intensive research, no satisfactory therapeutic options have been found for aging
and age-related diseases. The British scientist Leslie Orgel stated that evolution is cleverer …

Mass spectrometry‐based metabolomics has emerged as a powerful technique for
biomedical research, although technical issues with its analytical precision and structural …

Oxidative stress and decreased DNA damage repair in vertebrates increase with age also
due to lowered cellular NAD+. NAD+ depletion may play a major role in the aging process at …

Intracellular amine metabolite changes were quantified from hyperglycemic human aortic
endothelial cells (HAECs) as a model for macrovascular complications of diabetes. Amines …

Simple Summary Oncometabolites are produced by cancer cells and assist the cancer to
proliferate and progress. Oncometabolites occur as a result of mutated enzymes in the tumor …

Understanding the complexity of aging is of utmost importance. This can now be addressed
by the novel and powerful approach of metabolomics. However, to date, only a few …

Chemical modifications of DNA and RNA regulate genome functions or trigger mutagenesis
resulting in aging or cancer. Oxidations of macromolecules, including DNA, are common …