Severe ulcerative colitis (UC) is a potentially life-threatening disease with a potential
colorectal cancer (CRC) risk. The aim of this study was to explore the relationship between …

DNA methylation has been implied to play a role in the immune dysfunction associated with
inflammatory bowel disease (IBD) and the disease development of ulcerative colitis (UC) …

Abstract Background and Aims The aim of this study was to investigate the genome-wide
DNA methylation status in treatment-naïve ulcerative colitis [UC], and to explore the …

BACKGROUND: DNA methylation is considered one of the epigenetic mechanisms believed
to play a role in the pathogenesis of ulcerative colitis (UC). The aim of this study was to …

Background In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel
disease patients reflect inflammatory status rather than disease status. Here, we examined …

Introduction Aberrant DNA methylation frequently occurs in the inflammatory mucosa in
ulcerative colitis (UC) and is involved in UC-related tumorigenesis. We performed …

The cause of inflammatory bowel disease (IBD) is still unknown, but there is growing
evidence that environmental factors such as epigenetic changes can contribute to the …

Background: Ulcerative colitis (UC) is an idiopathic disease of the large intestine with
evidence pointing to the role of epigenetic changes. Methods: Searches were performed in …

The etiology of inflammatory bowel diseases is only partially explained by the current
genetic risk map. It is hypothesized that environmental factors modulate the epigenetic …

Background Epithelial-to-mesenchymal transition (EMT) is a phenomenon that allows the
conversion of adherent epithelial cells to a mesenchymal cell phenotype, which enhances …