Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

Epigenetic alterations are a hallmark of aging and age‐related diseases. Computational
models using DNA methylation data can create “epigenetic clocks” which are proposed to …

Aging clocks dissociate biological from chronological age. The estimation of biological age
is important for identifying gerontogenes and assessing environmental, nutritional, or …

The aim of this work was to provide an overview of the genetics of human ageing to gain
novel insights about the mechanisms involved. By incorporating findings from model …

Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …

Biological aging reflects decline in physiological functions and is an effective indicator of
morbidity and mortality. Numerous epigenetic age calculators are available, however …

Aging is a complex, challenging phenomenon that requires multiple, interdisciplinary
approaches to unravel its puzzles. To assist basic research on aging, we developed the …

The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …

The development of 'age clocks', machine learning models predicting age from biological
data, has been a major milestone in the search for reliable markers of biological age and …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …