Quantifying biological aging is critical for understanding why aging is the primary driver of
morbidity and mortality and for assessing novel therapies to counter pathological aging. In …

Aging is closely related to the occurrence of human diseases; however, its exact biological
mechanism is unclear. Advancements in high-throughput technology provide new …

Background Diagnostics of the human ageing process may help predict future healthcare
needs or guide preventative measures for tackling diseases of older age. We take a …

Aging in humans is an incredibly complex biological process that leads to increased
susceptibility to various diseases. Understanding which genes are associated with healthy …

Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …

The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

First published in 2016, predictors of chronological and biological age developed using
deep learning (DL) are rapidly gaining popularity in the aging research community. These …