The solved and unsolved mysteries of the genetics of early-onset Alzheimer's disease

E Rogaeva - Neuromolecular medicine, 2002 - Springer
Approximately half of the Alzheimer's disease (AD) cases that are associated with early
onset appear to be transmitted as a pure genetic, autosomal dominant trait. Genetic …

Molecular genetics of Alzheimer disease

PH St George-Hyslop - Seminars in neurology, 1999 - thieme-connect.com
Epidemiological and individual case studies indicate that genetic factors play a significant
role in the genesis of Alzheimer Disease (AD). To date, molecular genetic studies in families …

Function and dysfunction of the presenilins

SS Sisodia, SH Kim, G Thinakaran - The American Journal of Human …, 1999 - cell.com
Alzheimer disease (AD), a progressive neurodegenerative disorder, is the most common
type of dementia, occurring in mid to late life. The neuropathological hallmarks of this …

The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins

DJ Selkoe - Neurologic clinics, 2000 - neurologic.theclinics.com
Few experiences in the work of a neurologic diagnostician are more disquieting than
informing both patient and family that the diagnosis is Alzheimer's disease (AD). Yet, with the …

Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations

A Lleó, O Berezovska, JH Growdon… - The American journal of …, 2004 - Elsevier
Three genes have been implicated in the etiology of early-onset autosomal-dominant
Alzheimer disease (AD): the amyloid precursor protein, the presenilin-1, and presenilin-2 …

Insight into the genetic etiology of Alzheimer's disease: A comprehensive review of the role of rare variants

J Hoogmartens, R Cacace… - … & Dementia: Diagnosis …, 2021 - Wiley Online Library
Early‐onset Alzheimer's disease (EOAD) is generally known as a dominant disease due to
highly penetrant pathogenic mutations in the amyloid precursor protein, presenilin 1 and 2 …

Molecular genetics of Alzheimer's disease

PH St George-Hyslop - Biological psychiatry, 2000 - Elsevier
Application of genetic paradigms to Alzheimer's disease (AD) has led to confirmation that
genetic factors play a role in this disease. Additionally, researchers now understand that AD …

Molecular genetics of Alzheimer's disease: the role of β-amyloid and the presenilins

A Tandon, E Rogaeva, M Mullan… - Current Opinion in …, 2000 - journals.lww.com
Alzheimer's disease is the most common neurodegenerative disorder of aging, accounting
for an estimated two-thirds of all cases of senile dementia. Epidemiologic studies have failed …

The genetics of Alzheimer disease

RE Tanzi - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
Family history is the second strongest risk factor for Alzheimer disease (AD) following
advanced age. Twin and family studies indicate that genetic factors are estimated to play a …

Genetic risk factors in familial Alzheimer's disease

S Sorbi, P Forleo, A Tedde, E Cellini, M Ciantelli… - Mechanisms of ageing …, 2001 - Elsevier
In the last 10 years significant progress has been made to describe and identify the
underlying biological mechanisms that cause the different manifestation of Alzheimer's …