It is well established that gene expression levels in many organisms change during the
aging process, and the advent of DNA microarrays has allowed genome-wide patterns of …

Previous studies have suggested that there are genes whose expression levels are
associated with chronological age. However, which genes show consistent age association …

To characterize the promoterome of caudate and putamen regions (striatum), frontal and
temporal cortices, and hippocampi from aged human brains, we used high-throughput cap …

We present the AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene
expression database, which is a resource that catalogs changes in gene expression as a …

Although molecular features underlying aging and species maximum lifespan (MLS) have
been comprehensively studied by transcriptome analyses, the actual impact of transcriptome …

Aging of the human brain is associated with “normal” functional, structural, and molecular
changes that underlie alterations in cognition, memory, mood and motor function, amongst …

Ageing of the brain leads to impairments in cognitive and motor skills, and is the major risk
factor for several common neurological disorders such as Alzheimer disease (AD) and …

Highlights•Aging transcriptomes consist of regulated and dysregulated gene expression
changes.•Dysregulated transcriptional changes can be random (noise) or non-random …

Changes in gene expression levels determine differentiation of tissues involved in
development and are associated with functional decline in aging. Although development is …

A better understanding of the molecular effects of aging in the brain may help to reveal
important aspects of organismal aging, as well as processes that lead to age-related brain …