Metabolic changes are hallmarks of aging and genetic and pharmacologic alterations of
relevant pathways can extend life span. In this review, we will outline how cellular …

Here we review the environmental and genetic manipulations that link cellular and
organismal metabolism to aging. In particular, we explore how nutrients are sensed and how …

Perturbation of metabolism elicits cellular stress which profoundly modulates the cellular
proteome and thus protein homeostasis (proteostasis). Consequently, changes in the …

A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose
homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing …

Abstract The NIH Summit, Advances in Geroscience: Impact on Health Span and Chronic
Disease, discusses several aspects of cellular degeneration that underlie susceptibility to …

Evidence supports the notion that metabolic pathways are major regulators of organismal
aging, and that metabolic perturbations can extend health-and lifespan. For this reason …

Aging and longevity are controlled by a multiplicity of molecular and cellular signaling
events that interface with environmental factors to maintain cellular homeostasis. Modulation …

Genetic and pharmacological intervention studies have identified evolutionarily conserved
and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing …

Cellular and organ metabolism affects organismal lifespan. Aging is characterized by
increased risks for metabolic disorders, with age-associated degenerative diseases …

Cellular, small invertebrate and vertebrate models are a driving force in biogerontology
studies. Using various models, such as yeasts, appropriate tissue culture cells, Drosophila …