Frailty is a complex syndrome affecting a growing sector of the global population as medical
developments have advanced human mortality rates across the world. Our current …

Current research on human aging has largely been guided by the milestone paper
“hallmarks of aging,” which were first proposed in the seminal 2013 paper by Lopez‐Otin et …

Mitochondria are eukaryotic organelles known best for their roles in energy production and
metabolism. While often thought of as simply the 'powerhouse of the cell,'these organelles …

This innovative reference explores a wide selection of topics associated with aging,
providing a solid understanding of the significance and molecular basis of the aging process …

Mitochondrial dysfunction and cellular senescence are hallmarks of aging. However, the
relationship between these two phenomena remains incompletely understood. In this study …

There has recently been significant progress in our understanding of the mechanisms that
regulate ageing, and it has been shown that changes in single genes can dramatically …

This review addresses the data that support the presence and contribution of decreased
mitochondrial oxidative phosphorylation during aging to impaired cellular metabolism. Aging …

Age is one of the major risk factors associated with cardiovascular disease (CVD). About
one‐fifth of the world population will be aged 65 or older by 2030, with an exponential …

The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to
manipulate it has fascinated humans likely since time immemorial. Recent evidence is …

Accelerated biological aging, which involves the gradual decline of organ or tissue functions
and the distortion of physiological processes, underlies several human diseases. Away from …