Mutations in gene regulatory elements have been associated with a wide range of complex
neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in …

Most neuropsychiatric disease risk variants are in noncoding sequences and lack functional
interpretation. Because regulatory sequences often reside in open chromatin, we reasoned …

Common genetic risk for neuropsychiatric disorders is enriched in regulatory elements
active during cortical neurogenesis. However, it remains poorly understood as to how these …

Most disease variants lie within noncoding genomic regions, making their functional
interpretation challenging. Because chromatin openness strongly influences transcriptional …

Most common genetic risk variants associated with neuropsychiatric disease are noncoding
and are thought to exert their effects by disrupting the function of cis regulatory elements …

Editorial summary Breakthroughs on many fronts have provided strong evidence to support
synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have …

Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …

The genetic architecture of psychiatric disorders is characterized by a large number of small-
effect variants located primarily in non-coding regions, suggesting that the underlying causal …

Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …

Over the past decade, large-scale genetic studies have successfully identified hundreds of
genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic …