Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature
E Berson, A Sreenivas, T Phongpreecha… - Nature …, 2023 - nature.com
Abstract Assay for Transposase Accessible Chromatin by sequencing (ATAC-seq)
accurately depicts the chromatin regulatory state and altered mechanisms guiding gene …
accurately depicts the chromatin regulatory state and altered mechanisms guiding gene …
Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion
Recent work has identified dozens of non-coding loci for Alzheimer's disease (AD) risk, but
their mechanisms and AD transcriptional regulatory circuitry are poorly understood. Here …
their mechanisms and AD transcriptional regulatory circuitry are poorly understood. Here …
A comparative atlas of single-cell chromatin accessibility in the human brain
Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and
glial cell types within the human brain. However, the regulatory programs governing cell …
glial cell types within the human brain. However, the regulatory programs governing cell …
The three-dimensional landscape of cortical chromatin accessibility in Alzheimer's disease
To characterize the dysregulation of chromatin accessibility in Alzheimer's disease (AD), we
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …
Characterizing dysregulations via cell-cell communications in Alzheimer's brains using single-cell transcriptomes
Background Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting
44 million people worldwide, leading to cognitive decline, memory loss, and significant …
44 million people worldwide, leading to cognitive decline, memory loss, and significant …
Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease
Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
Cell type-specific changes identified by single-cell transcriptomics in Alzheimer's disease
The rapid advancement of single-cell transcriptomics in neurology has allowed for profiling
of post-mortem human brain tissue across multiple diseases. Over the past 3 years, several …
of post-mortem human brain tissue across multiple diseases. Over the past 3 years, several …
A single-cell and spatial RNA-seq database for Alzheimer's disease (ssREAD)
Alzheimer's Disease (AD) pathology has been increasingly explored through single-cell and
single-nucleus RNA-sequencing (scRNA-seq & snRNA-seq) and spatial transcriptomics …
single-nucleus RNA-sequencing (scRNA-seq & snRNA-seq) and spatial transcriptomics …
Avoiding false discoveries in single-cell RNA-seq by revisiting the first Alzheimer's disease dataset
Mathys et al. conducted the first single-nucleus RNA-seq (snRNA-seq) study of Alzheimer's
disease (AD)(Mathys et al., 2019). With bulk RNA-seq, changes in gene expression across …
disease (AD)(Mathys et al., 2019). With bulk RNA-seq, changes in gene expression across …
Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …