Although mutations in the genes encoding either the protein or RNA component of
telomerase have been found in patients with various blood disorders, the impact of telomere …

Age-associated telomere shortening is a well documented feature of peripheral blood cells
in human population studies, but it is not known to what extent these data can be transferred …

Background Telomere length is indicative of biological age. Shorter telomeres have been
associated with several disease and health states. There are inconsistencies throughout the …

Although telomere biology was revealed to play an important role in several hematopoietic
disorders, its impact on the age‐dependent dynamics of regular hematopoiesis is poorly …

Results: Of the 8892 eligible participants, 47.8%(n= 4123) were men. The mean age was
41.8 years overall, 41.0 years in men and 42.6 in women (p= 0.238). The sex-stratified …

Background: reduced telomere length in blood cells has been associated with increased risk
of multiple age-related diseases and is widely regarded as a general biomarker of ageing …

Telomerase activity is readily detectable in extracts from human hematopoietic stem and
progenitor cells, but appears unable to maintain telomere length with proliferation in vitro …

Humans display a large inter-individual variation in leukocyte telomere length (LTL), which
is influenced by heredity, sex, race/ethnicity, paternal age at conception and environmental …

Nonspecific chromosomal aberrations (CAs) are analyzed by microscopic scoring of
metaphase nuclei and they include fragmented, missing, or fused chromosomal segments …

The determinants and biomedical consequences of variation in leukocyte telomere length
(LTL), a proposed marker of biological age, are only partially understood. Here we report the …