Different psychiatric disorders as well as exposure to adverse life events have individually
been associated with multiple age-related diseases and mortality. Age acceleration in …

Individuals of the same chronological age exhibit disparate rates of biological ageing.
Consequently, a number of methodologies have been proposed to determine biological age …

Background Major depressive disorder (MDD) is a severe, heritable psychiatric disorder
associated with shortened lifespan and comorbidities of advancing age. It is unknown …

Background Neighborhood deprivation and depression have been linked to epigenetic age
acceleration. The next-generation epigenetic clocks including the DNA methylation (DNAm) …

Psychiatric disorders are associated with accelerated aging and enhanced risk for
neurodegenerative disorders. Brain aging is associated with molecular, cellular, and …

Individuals with psychiatric disorders are at increased risk of age-related diseases and early
mortality. Recent studies demonstrate that this link between mental health and aging is …

Background Schizophrenia (SZ) is associated with increased all-cause mortality, smoking,
and age-associated proteins, yet multiple previous studies found no association between SZ …

Bipolar disorder (BD) has been previously associated with clinical signs of premature aging,
including accelerated epigenetic aging in blood and brain, and a steeper age-related …

Patients with severe mental disorders such as bipolar disorder (BD), schizophrenia (SCZ)
and major depressive disorder (MDD) show a substantial reduction in life expectancy …

Age-associated disease and disability are placing a growing burden on society. However,
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …