Is depression associated with accelerated aging? Mechanisms and implications

D Lindqvist, NM Simon, OM Wolkowitz - Neurobiology of Depression, 2019 - Elsevier
Depression is associated with early mortality and with an increased risk of developing
physical diseases that are more typically seen in the elderly. Moreover, depression may be …

Cellular aging in depression: permanent imprint or reversible process? An overview of the current evidence, mechanistic pathways, and targets for interventions

JE Verhoeven, D Revesz, OM Wolkowitz… - …, 2014 - Wiley Online Library
Depression might be associated with accelerated cellular aging. However, does this result in
an irreversible state or is the body able to slow down or recover from such a process …

[HTML][HTML] Telomere biology in mood disorders: an updated, comprehensive review of the literature

A Muneer, FA Minhas - Clinical Psychopharmacology and …, 2019 - ncbi.nlm.nih.gov
Major psychiatric disorders are linked to early mortality and patients afflicted with these
ailments demonstrate an increased risk of developing physical diseases that are …

Psychiatric disorders and leukocyte telomere length: underlying mechanisms linking mental illness with cellular aging

D Lindqvist, ES Epel, SH Mellon, BW Penninx… - Neuroscience & …, 2015 - Elsevier
Many psychiatric illnesses are associated with early mortality and with an increased risk of
developing physical diseases that are more typically seen in the elderly. Moreover, certain …

Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress-preliminary findings

OM Wolkowitz, SH Mellon, ES Epel, J Lin, FS Dhabhar… - PloS one, 2011 - journals.plos.org
Background Depression is associated with an unusually high rate of aging-related illnesses
and early mortality. One aspect of “accelerated aging” in depression may be shortened …

Telomeres: the role of shortening and senescence in major depressive disorder and its therapeutic implications

JD Schroder, JB de Araújo, T de Oliveira… - Reviews in the …, 2022 - degruyter.com
Major depressive disorder (MDD) is one of the most prevalent and debilitating psychiatric
disorders, with a large number of patients not showing an effective therapeutic response to …

Exploring the link between depression and accelerated cellular aging: telomeres hold the key

R Yu, J Woo - Research and Reports in Biochemistry, 2015 - Taylor & Francis
Accumulating evidence suggests that telomeres may be a marker for biological aging and
telomere length may be affected by multifactorial influences, including cumulative exposure …

Leukocyte telomere length is reduced in patients with major depressive disorder

C Pisanu, EE Tsermpini, M Skokou… - Drug development …, 2020 - Wiley Online Library
Major depressive disorder (MDD) is a chronic, severe psychiatric illness with an incidence of
3% worldwide. MDD patients have a significantly impaired quality of life and reduced life …

Shortened telomere length in patients with depression: a meta-analytic study

PY Lin, YC Huang, CF Hung - Journal of Psychiatric Research, 2016 - Elsevier
Background Accelerated telomere shortening is associated with stress-related cell damage
and aging. Patients with depression have been shown to have shortened life expectancy …

Telomere shortening in late‐life depression: a potential marker of depression severity

AP Mendes‐Silva, ELM Vieira, G Xavier… - Brain and …, 2021 - Wiley Online Library
Objectives Telomeres are structures at the extremity of chromosomes that prevents genomic
instability, and its shortening seems to be a hallmark of cellular aging. Past studies have …