A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology …
AB Newman, S Walter, KL Lunetta… - … Series A: Biomedical …, 2010 - academic.oup.com
Background. Genome-wide association studies (GWAS) may yield insights into longevity.
Methods. We performed a meta-analysis of GWAS in Caucasians from four prospective …
Methods. We performed a meta-analysis of GWAS in Caucasians from four prospective …
GWAS and meta-analysis in aging/longevity
L Broer, CM van Duijn - Longevity Genes: A Blueprint for Aging, 2015 - Springer
Longevity is an extremely complex phenotype that is determined by environment, life style
and genetics. Genome wide association studies (GWAS) have been a powerful tool to …
and genetics. Genome wide association studies (GWAS) have been a powerful tool to …
The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals
JM Murabito, R Yuan, KL Lunetta - Journals of Gerontology …, 2012 - academic.oup.com
Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …
the identification of the underlying genes remains a challenge. Longevity is a complex …
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies …
Background—The primary aim of genome-wide association studies is to identify novel
genetic loci associated with interindividual variation in the levels of risk factors, the degree of …
genetic loci associated with interindividual variation in the levels of risk factors, the degree of …
[HTML][HTML] A genome-wide association study of aging
Human longevity and healthy aging show moderate heritability (20%–50%). We conducted
a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for …
a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for …
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study
Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …
identifying genes associated with longer lives. To identify such longevity alleles, we …
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
The genetic contribution to the variation in human lifespan is∼ 25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence …
number of identified disease-susceptibility loci, it is not known which loci influence …
Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity
M Beekman, C Nederstigt… - Proceedings of the …, 2010 - National Acad Sciences
A set of currently known alleles increasing the risk for coronary artery disease, cancer, and
type 2 diabetes as identified by genome-wide association studies was tested for …
type 2 diabetes as identified by genome-wide association studies was tested for …