Many of the genes that affect aging and longevity in model organisms, such as mice, fruit
flies, and worms, have human homologs. This article reviews several genetic pathways that …

The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …

Longevity, ie, the property of being long-lived, has its natural limitation in the aging process.
Longevity has a strong genetic component, as has become apparent from studies with a …

There is a substantial distinction to be made between the genetics of aging and the genetics
of exceptional longevity. Twin studies suggest that the average set of genetic variations …

There is an intense search for longevity genes in both animal models and humans. Human
family studies have indicated that a modest amount of the overall variation in adult lifespan …

Once thought to be an extremely complex conundrum of weak genetic and environmental
effects, exceptional longevity is beginning to yield genetic findings. Numerous lower …

Over the last 30 years, a number of genetic and environmental factors that lead to decreased
length of life have been identified. Unfortunately, much less progress has been achieved in …

Centenarians represent an extreme of life expectancy. They achieve their exceptional
longevity in part by lacking genetic variations linked to premature death. Pedigree studies …

Aging is due to a complex interaction of genetic, epigenetic, and environmental factors, but a
strong genetic component appears to have an impact on survival to extreme ages. In order …

Unlocking the Secrets Page 1 48 SCIENTIFIC AMERICAN MARCH 2006 CRE D IT Unlocking
the Secrets of Longevity Genes A handful of genes that control the body’s defenses during hard …