Lifespan varies significantly among mammals, with more than 100‐fold difference between
the shortest and longest living species. This natural difference may uncover the evolutionary …

Mammals differ more than 100‐fold in maximum lifespan, which can be altered in either
direction during evolution, but the molecular basis for natural changes in longevity is not …

Aging is thought to occur through the accumulation of biochemical damage affecting DNA,
proteins, and lipids. The major source of cellular damage involves the generation of reactive …

Although lifespan in mammals varies over 100-fold, the precise evolutionary mechanisms
underlying variation in longevity remain unknown. Species-specific genetic changes have …

Studies in invertebrate model organisms have been a driving force in aging research,
leading to the identification of many genes that influence life span. Few of these genes have …

A recent paper by Deelen et al.(2014) in Human Molecular Genetics reports the largest
genome-wide association study of human longevity to date. While impressive, there is a …

Ample evidence from model organisms has indicated that subtle variation in genes can
dramatically influence lifespan. The key genes and molecular pathways that have been …

Although molecular features underlying aging and species maximum lifespan (MLS) have
been comprehensively studied by transcriptome analyses, the actual impact of transcriptome …

Aging is a complex and highly variable process. Heritability of longevity among humans and
other species is low, and this finding has given rise to the idea that it may be futile to search …

Much of the current research on longevity focuses on the aging process within a single
species. Several molecular players (eg IGF1 and MTOR), pharmacological compounds (eg …