For Alzheimer's disease (AD), aging is the main risk factor, but whether cognitive
impairments due to aging resemble early AD deficits is not yet defined. When working with …

To fight Alzheimer's disease (AD), we should know when, where, and how brain network
dysfunctions initiate. In AD mouse models, relevant information can be derived from brain …

Age-dependent accumulation of amyloid-β, provoking increasing brain amyloidopathy,
triggers abnormal patterns of neuron activity and circuit synchronization in Alzheimer's …

Amyloidopathy involves the accumulation of insoluble amyloid β (Aβ) species in the brain's
parenchyma and is a key histopathological hallmark of Alzheimer's disease (AD). Work on …

Background Studies in animal models of Alzheimer's disease (AD) have provided valuable
insights into the molecular and cellular processes underlying neuronal network dysfunction …

Alterations of brain network activity are observable in Alzheimer's disease (AD) together with
the occurrence of mild cognitive impairment, before overt pathology. However, in humans as …

Life-time experiences are thought to influence the risk to develop the neurodegenerative
disorder Alzheimer's disease (AD). In particular, early-life stress (ES) may modulate the …

The transgenic mouse line PS2APP (PS2N141I× APPswe) develops an age-related
cognitive decline associated with severe amyloidosis, mimicking the pathophysiologic …

Multiple animal models have been created to gain insight into Alzheimer's disease (AD)
pathology. Among the most commonly used models are transgenic mice overexpressing …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by
memory loss and impaired cognitive function. One of the hallmarks of AD is the formation of …