Homocysteine (Hcy) is a vascular risk factor associated with cognitive impairment and
cerebrovascular disease but has also been implicated in Alzheimer's disease (AD). Using …

The progressive development of Alzheimer disease (AD)-related lesions, such as
neurofibrillary tangles (NFT), amyloid deposits and synaptic loss, and the occurrence of …

NIA-AA diagnostic criteria include volumetric or visual rating measures of hippocampal
atrophy (HA) as a diagnostic biomarker of Alzheimer's disease (AD). We aimed to determine …

Alzheimer's disease (AD) is characterized by neurofibrillary tangle and neuropil thread
deposition, which ultimately results in neuronal loss. A large number of magnetic resonance …

Different clinical variants of probable Alzheimer's disease (AD) share underlying plaques
and tangles but show distinct atrophy patterns. We included 52 posterior cortical atrophy, 29 …

The pathophysiological processes underlying Alzheimer's disease (AD) are hypothesized to
begin years to decades before clinical symptom onset, while individuals are still cognitively …

Objectives: To assess the diagnostic specificity of MRI-defined hippocampal atrophy for AD
among individuals with a variety of pathologically confirmed conditions associated with …

We investigated the relationship between vascular disease and risk factors versus cognitive
decline cross-sectionally and longitudinally in normal older control, mild cognitive …

There is compelling evidence for the early involvement of the hippocampal formation in the
natural history of Alzheimer's disease (AD). The evidence comes from recent …

In a neuropathological study of 81 brains of prospectively studied subjects of 80 years of age
or older at the time of death, 13 cases (16%), including 4 men and 9 women, had …