Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults

D Putcha, M Brickhouse, K O'Keefe… - Journal of …, 2011 - Soc Neuroscience
Alzheimer's disease (AD) is associated with functional and structural alterations in a
distributed network of brain regions supporting memory and other cognitive domains …

A systematic review and meta-analysis of longitudinal hippocampal atrophy in healthy human ageing

MA Fraser, ME Shaw, N Cherbuin - Neuroimage, 2015 - Elsevier
Introduction This review aimed to produce hippocampal atrophy rate estimates from healthy
ageing studies as well as control samples from observational studies across the adult …

Vascular risk factors are associated with faster decline of Alzheimer disease: a longitudinal SPECT study

K Kume, H Hanyu, T Sato, K Hirao, S Shimizu… - Journal of …, 2011 - Springer
We investigated the effects of cardiovascular risk factors, such as hypertension, diabetes
mellitus, and hypercholesterolemia, on longitudinal regional cerebral blood flow (rCBF) …

Distinct profiles of brain and cognitive changes in the very old with Alzheimer disease

NH Stricker, YL Chang, C Fennema-Notestine… - Neurology, 2011 - AAN Enterprises
Objective: To determine whether age-standardized brain morphometric and cognitive
profiles differ in young-old (aged 60–75 years) and very-old (aged 80–91 years) patients …

Relationship between hippocampal atrophy and neuropathology markers: A 7T MRI validation study of the EADC‐ADNI Harmonized Hippocampal Segmentation …

LG Apostolova, C Zarow, K Biado, S Hurtz… - Alzheimer's & …, 2015 - Wiley Online Library
Objective The pathologic validation of European Alzheimer's Disease Consortium
Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal …

The dynamics of cortical and hippocampal atrophy in Alzheimer disease

MR Sabuncu, RS Desikan, J Sepulcre… - Archives of …, 2011 - jamanetwork.com
Objective To characterize rates of regional Alzheimer disease (AD)–specific brain atrophy
across the presymptomatic, mild cognitive impairment, and dementia stages. Design …

Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a …

AJ Dugan, PT Nelson, Y Katsumata… - Acta Neuropathologica …, 2021 - Springer
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) is the most prevalent subtype of TDP-43 proteinopathy, affecting up to 1/3rd of aged …

Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease

SG Mueller, N Schuff, K Yaffe, C Madison… - Human brain …, 2010 - Wiley Online Library
Background: Histopathological studies and animal models suggest that hippocampal
subfields may be differently affected by aging, Alzheimer's disease (AD), and other diseases …

Summative effects of vascular risk factors on cortical thickness in mild cognitive impairment

E Tchistiakova, BJ MacIntosh… - Neurobiology of …, 2016 - Elsevier
Vascular risk factors (VRFs) increase the risk of Alzheimer's disease (AD) and contribute to
neurodegenerative processes. The purpose of this study was to investigate whether …

Distinct spatiotemporal patterns of cortical thinning in Alzheimer's disease-type cognitive impairment and subcortical vascular cognitive impairment

J Kim, J Kim, Y Park, H Yoo, JP Kim, H Jang… - Communications …, 2024 - nature.com
Previous studies on Alzheimer's disease-type cognitive impairment (ADCI) and subcortical
vascular cognitive impairment (SVCI) has rarely explored spatiotemporal heterogeneity. This …