Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility

J Theuns, C Van Broeckhoven - Human molecular genetics, 2000 - academic.oup.com
In recent years, important progress has been made in uncovering genes implicated in
Alzheimer's disease (AD). Three causal genes have been identified in which mutations …

[HTML][HTML] Molecular biology and genetics of Alzheimer's disease

PH St George-Hyslop, A Petit - Comptes rendus biologies, 2005 - Elsevier
Like several other adult onset neurodegenerative diseases, Alzheimer's disease is a
multifactorial illness with both genetic and non-genetic causes. Recent genetic studies have …

Genes and susceptible loci of Alzheimer's disease

BS Shastry, FJ Giblin - Brain research bulletin, 1999 - Elsevier
Alzheimer's disease (AD) is the most common and devastating neurodegenerative disease
of the elderly. Many research findings on familial AD suggest that the mechanisms of the …

Genetic complexity of Alzheimer's disease: successes and challenges

E Rogaeva, T Kawarai… - Journal of Alzheimer's …, 2006 - content.iospress.com
Abstract About 1% of Alzheimer's Disease (AD) cases have an early-onset autosomal
dominant familial form of the disease, genetic analyses of which have found three causal …

Candidate gene association studies in sporadic Alzheimer's disease

O Combarros, A Alvarez-Arcaya… - Dementia and geriatric …, 2002 - karger.com
The genetics of Alzheimer's disease (AD) is complex. Three genes (amyloid precursor
protein, presenilin 1 and presenilin 2) have been described in the relatively rare, early …

The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins

DJ Selkoe - Neurologic clinics, 2000 - neurologic.theclinics.com
Few experiences in the work of a neurologic diagnostician are more disquieting than
informing both patient and family that the diagnosis is Alzheimer's disease (AD). Yet, with the …

Transcriptional regulation and its misregulation in Alzheimer's disease

XF Chen, Y Zhang, H Xu, G Bu - Molecular brain, 2013 - Springer
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by loss
of memory and cognitive function. A key neuropathological event in AD is the accumulation …

Genetic underpinnings in Alzheimer's disease–a review

AA Moustafa, M Hassan, DH Hewedi… - Reviews in the …, 2017 - degruyter.com
In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore,
we review genetic links to protein signaling pathways as novel pharmacological targets to …

Molecular genetics of Alzheimer's disease: an update

N Brouwers, K Sleegers, C Van Broeckhoven - Annals of medicine, 2008 - Taylor & Francis
Alzheimer's disease (AD) is a complex disorder of the central nervous system (CNS).
Molecular genetic research has provided a wealth of information regarding the genetic …

The genetics of Alzheimer's disease

GD Schellenberg, I D'Souza, P Poorkaj - Current psychiatry reports, 2000 - Springer
Alzheimer's disease (AD) is a genetically complex disorder. Mutations in the amyloid
precursor protein and presenilin 1 (PS1) genes are fully penetrant and cause early-onset …