[HTML][HTML] Accumulation of aberrant DNA methylation during colorectal cancer development

E Sakai, A Nakajima, A Kaneda - World Journal of …, 2014 - ncbi.nlm.nih.gov
Despite the recent advances in the therapeutic modalities, colorectal cancer (CRC) remains
to be one of the most common causes of cancer-related death. CRC arises through …

DNA methylation markers in colorectal cancer

MS Kim, J Lee, D Sidransky - Cancer and Metastasis Reviews, 2010 - Springer
Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicine

N Fatemi, S Tierling, HA Es, M Varkiani… - … journal of cancer, 2022 - Wiley Online Library
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is
attributed to gradual long‐term accumulation of both genetic and epigenetic changes. To …

Role of DNA methylation in colorectal carcinogenesis

ÁV Patai, B Molnár, A Kalmár, A Schöller, K Tóth… - Digestive …, 2012 - karger.com
Colorectal cancer is the most common malignancy of the gastrointestinal tract and a leading
cause of cancer-related deaths worldwide. In order to detect early precursor lesions …

Genomic effect of DNA methylation on gene expression in colorectal cancer

J Hong, JK Rhee - Biology, 2022 - mdpi.com
Simple Summary Abnormal DNA methylation is known to regulate gene expression, and its
features have been frequently observed in colorectal cancer (CRC) patients. In addition …

Epigenetic biomarkers of colorectal cancer: Focus on DNA methylation

F Coppedè - Cancer letters, 2014 - Elsevier
The original theory of the multi-step process of colorectal cancer (CRC), suggesting that the
disease resulted from the accumulation of mutations in oncogenes and tumor suppressor …

Epigenetics and colorectal cancer

VV Lao, WM Grady - Nature reviews Gastroenterology & hepatology, 2011 - nature.com
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

Noninvasive DNA methylation biomarkers in colorectal cancer: a systematic review

M Xue, SC Lai, ZP Xu, LJ Wang - Journal of digestive diseases, 2015 - Wiley Online Library
Objective To summarize the current evidence on the biomarkers associated with DNA
methylation in the screening and diagnosis of colorectal cancer (CRC). Methods A literature …

DNA methylation in colorectal cancer—impact on screening and therapy monitoring modalities?

M Zitt, M Zitt, HM Müller - Disease markers, 2007 - Wiley Online Library
Colorectal cancer (CRC) is a common malignancy. It arises from benign neoplasms and
evolves into adenocarcinomas through a stepwise histological progression sequence …

DNA methylation patterns as noninvasive biomarkers and targets of epigenetic therapies in colorectal cancer

Y Hashimoto, TJ Zumwalt, A Goel - Epigenomics, 2016 - Taylor & Francis
Aberrant DNA methylation is frequently detected in gastrointestinal tumors, and can
therefore potentially be used to screen, diagnose, prognosticate, and predict colorectal …