Three‐year change in inflammatory markers in elderly people and mortality: The Invecchiare in Chianti Study

DE Alley, E Crimmins… - Journal of the …, 2007 - Wiley Online Library
OBJECTIVES: To describe changes in interleukin‐6 (IL‐6) and C‐reactive protein (CRP)
and to determine how changes are related to mortality in elderly people. DESIGN …

Interleukin‐6, C‐reactive protein, and tumor necrosis factor‐alpha as predictors of mortality in frail, community‐living elderly individuals

S Giovannini, G Onder, R Liperoti… - Journal of the …, 2011 - Wiley Online Library
OBJECTIVES: To investigate whether interleukin‐6 (IL‐6), C‐reactive protein (CRP) and
tumor necrosis factor‐alpha (TNF‐α) protein levels predict all‐cause mortality in older …

Long‐term variability of inflammatory markers and associated factors in a population‐based cohort

SD Nash, KJ Cruickshanks, R Klein… - Journal of the …, 2013 - Wiley Online Library
Objectives To investigate long‐term variability in serum high‐sensitivity C‐reactive protein
(CRP) and interleukin‐6 (IL‐6) and to determine associated risk factors for high‐risk …

Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study

M Gallucci, GP Amici, F Ongaro, GB Gajo… - Archives of gerontology …, 2007 - Elsevier
IL-6 expression is regulated by the interplay of several transcriptional and hormonal factors,
including sex steroids and glucocorticoids. In late life IL-6 expression increases as a result …

Long-term assessment of inflammation and healthy aging in late life: the Cardiovascular Health Study All Stars

NS Jenny, B French, AM Arnold… - … Series A: Biomedical …, 2012 - academic.oup.com
Background. Associations of inflammation with age-related pathologies are documented;
however, it is not understood how changes in inflammation over time impact healthy aging …

Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study

M Jylhä, P Paavilainen, T Lehtimäki… - The Journals of …, 2007 - academic.oup.com
Background. Inflammation plays a major role in both aging and chronic disease.
Longitudinal studies in very old people can improve our understanding of these processes …

Interleukin-6 as a first-rated serum inflammatory marker to predict mortality and hospitalization in the oldest old: A regression and CART approach in the BELFRAIL …

W Adriaensen, C Matheï, B Vaes… - Experimental …, 2015 - Elsevier
Background Certain inflammatory biomarkers increase with age, provide information about
general burden of illness and could cause or reflect any collateral damage to healthy cells …

Predictors of interleukin‐6 elevation in older adults

S Zhu, KV Patel, S Bandinelli, L Ferrucci… - Journal of the …, 2009 - Wiley Online Library
OBJECTIVES: To investigate the characteristics of older adults who develop high interleukin‐
6 (IL‐6) levels at 3‐year follow‐up. DESIGN: Population‐based study of adults living in …

Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly

TB Harris, L Ferrucci, RP Tracy, MC Corti… - The American journal of …, 1999 - Elsevier
PURPOSE: To investigate whether interleukin-6 and C-reactive protein levels predict all-
cause and cause-specific mortality in a population-based sample of nondisabled older …

Peripheral blood markers of inflammation predict mortality and functional decline in high‐functioning community‐dwelling older persons

DB Reuben, AI Cheh, TB Harris… - Journal of the …, 2002 - Wiley Online Library
OBJECTIVES: Several peripheral blood markers of inflammation have demonstrated
prognostic ability, but the value of combining multiple markers as a measure of inflammatory …