Aging is the major predictor for developing multiple neurodegenerative diseases, including
Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells …

Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

Aging is inevitable. Along with reduced ability to maintain the homeostasis of various
biological processes, aging gradually deteriorates overall health. Extensive research on the …

The influence of the activation of a cellular phenotype termed senescence and it's
importance in ageing and age-related diseases is becoming more and more evident. In fact …

Cellular senescence is a state of permanent cell-cycle arrest. Early in life, senescence has a
physiologic role in tumor suppression and wound healing. However, gradually, as these …

Cellular senescence is a primary aging process and tumor suppressive mechanism
characterized by irreversible growth arrest, apoptosis resistance, production of a …

Cellular senescence is a process in which cells change their characteristic phenotype in
response to stress and enter a state of prolonged cell cycle arrest accompanied by a distinct …

Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …

Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …