Genetic and phenotypic analysis of the causal relationship between aging and COVID-19

K Ying, R Zhai, TV Pyrkov, AV Shindyapina… - Communications …, 2021 - nature.com
Background Epidemiological studies revealed that the elderly and those with comorbidities
are most affected by COVID-19, but it is important to investigate shared genetic mechanisms …

Causal association of epigenetic aging and COVID-19 severity and susceptibility: A bidirectional Mendelian randomization study

W Xu, F Zhang, Y Shi, Y Chen, B Shi, G Yu - Frontiers in Medicine, 2022 - frontiersin.org
Observational data from China, the United States, France, and Italy suggest that
chronological age is an adverse COVID-19 outcome risk factor, with older patients having a …

Association analysis framework of genetic and exposure risks for COVID-19 in middle-aged and elderly adults

Y Zhang, H Yang, S Li, WD Li, J Wang… - Mechanisms of Ageing and …, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is a current pandemic, and studies reported
that older people have higher rates of infection and more severe cases. Recently, studies …

[HTML][HTML] Why does COVID-19 disproportionately affect older people?

AL Mueller, MS McNamara, DA Sinclair - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …

Biological aging predicts vulnerability to COVID-19 severity in UK Biobank participants

CL Kuo, LC Pilling, JL Atkins, JAH Masoli… - The Journals of …, 2021 - academic.oup.com
Background Age and disease prevalence are the 2 biggest risk factors for Coronavirus
disease 2019 (COVID-19) symptom severity and death. We therefore hypothesized that …

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality

T Nakanishi, S Pigazzini, F Degenhardt… - The Journal of …, 2021 - Am Soc Clin Investig
Background There is considerable variability in COVID-19 outcomes among younger adults,
and some of this variation may be due to genetic predisposition. Methods We combined …

Accelerated biological aging in COVID-19 patients

X Cao, W Li, T Wang, D Ran, V Davalos… - Nature …, 2022 - nature.com
Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous
findings indicate that epigenetic age could be altered in viral infection. However, the …

Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity

C Anastassopoulou, Z Gkizarioti, GP Patrinos… - Human genomics, 2020 - Springer
Background The emergence of the novel coronavirus in Wuhan, Hubei Province, China, in
December 2019 marked the synchronization of the world to a peculiar clock that is counting …

Centenarians and COVID-19: is there a link between longevity and better immune defense?

P Kordowitzki - Gerontology, 2022 - karger.com
Dear Editor, The French nun Sister André who is believed to be the world's second-oldest
person was celebrating her 117th birthday on February 11, 2021 after having a SARS-CoV …

A human circulating immune cell landscape in aging and COVID-19

Y Zheng, X Liu, W Le, L Xie, H Li, W Wen, S Wang… - Protein & …, 2020 - academic.oup.com
Age-associated changes in immune cells have been linked to an increased risk for infection.
However, a global and detailed characterization of the changes that human circulating …