[PDF][PDF] Inflammaging (inflammation+ aging): a driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?

M Goto - Bioscience trends, 2008 - researchgate.net
Aging, and especially human aging, can be explained by the emerging concept of
parainflammation-driven inflammaging, ie a combination of inflammation and aging …

The continuum of aging and age-related diseases: common mechanisms but different rates

C Franceschi, P Garagnani, C Morsiani, M Conte… - Frontiers in …, 2018 - frontiersin.org
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …

Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis

G Livshits, A Kalinkovich - Ageing research reviews, 2019 - Elsevier
Sarcopenia, obesity and their coexistence, obese sarcopenia (OBSP) as well as
atherosclerosis-related cardio-vascular diseases (ACVDs), including chronic heart failure …

[HTML][HTML] Redefining chronic inflammation in aging and age-related diseases: proposal of the senoinflammation concept

HY Chung, DH Kim, EK Lee, KW Chung… - Aging and …, 2019 - ncbi.nlm.nih.gov
Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …

Human inflammaging

T Fülöp, A Larbi, JM Witkowski - Gerontology, 2019 - karger.com
Human aging is a very complex process that occurs in an intricate biological and
physiological setting. Many changes occur with aging and among the most important are …

Metaflammation in obesity and its therapeutic targeting

MW Schleh, HL Caslin, JN Garcia… - Science translational …, 2023 - science.org
Obesity-associated inflammation is a systemic process that affects all metabolic organs.
Prominent among these is adipose tissue, where cells of the innate and adaptive immune …

Connecting aging biology and inflammation in the omics era

KA Walker, N Basisty, DM Wilson… - The Journal of Clinical …, 2022 - Am Soc Clin Investig
Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …

[HTML][HTML] Inflammaging and the Skin

SM Pilkington, S Bulfone-Paus, CEM Griffiths… - Journal of Investigative …, 2021 - Elsevier
As global life expectancy continues to rise, we are challenged with maintaining health into
old age. One strategy is to target the chronic low-level inflammation associated with aging …

From aging to long COVID: exploring the convergence of immunosenescence, inflammaging, and autoimmunity

L Müller, S Di Benedetto - Frontiers in Immunology, 2023 - frontiersin.org
The process of aging is accompanied by a dynamic restructuring of the immune response, a
phenomenon known as immunosenescence. This mini-review navigates through the …

Aging, obesity, and inflammatory age-related diseases

D Frasca, BB Blomberg, R Paganelli - Frontiers in immunology, 2017 - frontiersin.org
The increase in the prevalence of obesity represents a worldwide phenomenon in all age
groups and is pathologically and genetically correlated with several metabolic and …