The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson's disease

SYY Pang, PWL Ho, HF Liu, CT Leung, L Li… - Translational …, 2019 - Springer
Background Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the
substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During …

Mitochondrial dysfunction, protein misfolding and neuroinflammation in Parkinson's disease: roads to biomarker discovery

A Picca, F Guerra, R Calvani, R Romano… - Biomolecules, 2021 - mdpi.com
Parkinson's Disease (PD) is a highly prevalent neurodegenerative disease among older
adults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons …

Molecular pathogenesis of Parkinson disease

JL Eriksen, Z Wszolek, L Petrucelli - Archives of neurology, 2005 - jamanetwork.com
Parkinson disease (PD), the most common neurodegenerative movement disorder, is
characterized by an extensive and progressive loss of dopaminergic neurons in the …

Parkinson's disease risk factors: genetic, environmental, or both?

MF Allam, AS Del Castillo, RFC Navajas - Neurological research, 2005 - Taylor & Francis
Perhaps one of the most important questions posed by the neurobiology of aging concerns
the pathogenic mechanisms in Parkinson's disease (PD). Recently, it was suggested that …

Parkinson's disease genetics and pathophysiology

GE Vázquez-Vélez, HY Zoghbi - Annual review of neuroscience, 2021 - annualreviews.org
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
degeneration of the substantia nigra pars compacta and by accumulation of α-synuclein in …

Gene–environment interactions in Parkinson's disease

CA Ross, WW Smith - Parkinsonism & related disorders, 2007 - Elsevier
PD is the second most common neurodegenerative disease, and affects 5% of the
population by the age of 85. PD is a multi-factorial disease with a complex etiology including …

Parkinson's disease: a genetic perspective

AC Belin, M Westerlund - The FEBS journal, 2008 - Wiley Online Library
Parkinson's disease (PD) is a common neurodegenerative disorder in the aging population,
affecting more than 1% over the age of 65 years. Certain rare forms of the disease are …

Understanding multifactorial architecture of Parkinson's disease: pathophysiology to management

R Kaur, S Mehan, S Singh - Neurological Sciences, 2019 - Springer
Parkinson's disease (PD) is the second most common multifactorial neurodegenerative
disorder affecting 3% of population during elder age. The loss of substantia nigra, pars …

Cellular and molecular pathophysiology in the progression of Parkinson's disease

V Zaman, DC Shields, R Shams, KP Drasites… - Metabolic brain …, 2021 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder etiologically linked to the loss of
substantia nigra (SN) dopaminergic neurons in the mid-brain. The etiopathology of sporadic …

Recent advances in the genetics and pathogenesis of Parkinson disease

MM Mouradian - Neurology, 2002 - AAN Enterprises
The identification of three genes and several additional loci associated with inherited forms
of levodopa-responsive PD has confirmed that this is not a single disorder. Yet, analyses of …