A cohort autopsy study defines COVID-19 systemic pathogenesis

XH Yao, T Luo, Y Shi, ZC He, R Tang, PP Zhang, J Cai… - Cell research, 2021 - nature.com
Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by
dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS …

The origin and underlying driving forces of the SARS-CoV-2 outbreak

SM Chaw, JH Tai, SL Chen, CH Hsieh… - Journal of biomedical …, 2020 - Springer
Background SARS-CoV-2 began spreading in December 2019 and has since become a
pandemic that has impacted many aspects of human society. Several issues concerning the …

Evidence of severe acute respiratory syndrome coronavirus 2 replication and tropism in the lungs, airways, and vascular endothelium of patients with fatal coronavirus …

J Bhatnagar, J Gary, S Reagan-Steiner… - The Journal of …, 2021 - academic.oup.com
Background The coronavirus disease 2019 (COVID-19) pandemic continues to produce
substantial morbidity and mortality. To understand the reasons for the wide-spectrum …

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of …

H Chu, JFW Chan, Y Wang, TTT Yuen… - Clinical Infectious …, 2020 - academic.oup.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an
emerging coronavirus that has resulted in more than 2 000 000 laboratory-confirmed cases …

Comorbidities and clinical complications associated with SARS-CoV-2 infection: an overview

A Gupta, H Marzook, F Ahmad - Clinical and experimental medicine, 2023 - Springer
The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes major
challenges to the healthcare system. SARS-CoV-2 infection leads to millions of deaths …

[HTML][HTML] Pathology and pathogenesis of SARS-CoV-2 associated with fatal coronavirus disease, United States

RB Martines, JM Ritter, E Matkovic, J Gary… - Emerging infectious …, 2020 - ncbi.nlm.nih.gov
An ongoing pandemic of coronavirus disease (COVID-19) is caused by infection with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Characterization of the …

COVID-19 lung pathogenesis in SARS-CoV-2 autopsy cases

S Valdebenito, S Bessis, D Annane… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health
issue. COVID-19 is considered an airway/multi-systemic disease, and demise has been …

New insights of emerging SARS-CoV-2: epidemiology, etiology, clinical features, clinical treatment, and prevention

G Guo, L Ye, K Pan, Y Chen, D Xing, K Yan… - Frontiers in cell and …, 2020 - frontiersin.org
Since the first reports that the novel coronavirus was showing human-to-human transmission
characteristics and asymptomatic cases, the number of patients with associated pneumonia …

SARS‐CoV‐2: Mechanism of infection and emerging technologies for future prospects

S Li, S Li, C Disoma, R Zheng, M Zhou… - Reviews in Medical …, 2021 - Wiley Online Library
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has
spread globally to over 200 countries with more than 23 million confirmed cases and at least …

Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications

IP Trougakos, K Stamatelopoulos, E Terpos… - Journal of Biomedical …, 2021 - Springer
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying
pathobiology of COVID-19 will support the design of rational treatments targeting the life …