One of the most appreciated consequences of immunosenescence is an impaired response
to vaccines with advanced age. While most studies report impaired antibody responses in …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Older adults are more susceptible to viral and bacterial infection, and experience higher
incidence and severity of infectious diseases. Although vaccination is the most logical …

The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …

Aging is associated with declines in immune system function, or 'immunosenescence',
leading to progressive deterioration in both innate and adaptive immunity. These changes …

Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …

Successful vaccination of the elderly against important infectious pathogens that cause high
morbidity and mortality represents a growing public health priority. Building on the theme of …

Immunosenescence contributes to a decreased capacity of the immune system to respond
effectively to infections or vaccines in the elderly. The full extent of the biological changes …

Vaccination remains the most effective prophylactic intervention for infectious disease in the
healthcare professional's toolkit. However, the efficacy and effectiveness of vaccines …

Highlights•Aging is associated with a decline in immune function termed 'immune
senescence'.•Effective influenza vaccines need to be developed for better protection the …