A study of hypermethylated circulating tumor DNA as a universal colorectal cancer biomarker

S Garrigou, G Perkins, F Garlan, C Normand… - Clinical …, 2016 - academic.oup.com
Abstract BACKGROUND Circulating tumor DNA (ctDNA) has emerged as a good candidate
for tracking tumor dynamics in different cancer types, potentially avoiding repeated tumor …

Methylated circulating tumor DNA as a biomarker for colorectal cancer diagnosis, prognosis, and prediction

FJ Nassar, ZS Msheik, RR Nasr, SN Temraz - Clinical Epigenetics, 2021 - Springer
Worldwide, colorectal cancer (CRC) is a deadly disease whose death rate ranks second
among cancers though its incidence ranks third. Early CRC detection is key and is …

Evaluation of methylation biomarkers for detection of circulating tumor DNA and application to colorectal cancer

SM Mitchell, T Ho, GS Brown, RT Baker, ML Thomas… - Genes, 2016 - mdpi.com
Solid tumors shed DNA into circulation, and there is growing evidence that the detection of
circulating tumor DNA (ctDNA) has broad clinical utility, including monitoring of disease …

Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer

H Luo, Q Zhao, W Wei, L Zheng, S Yi, G Li… - Science translational …, 2020 - science.org
Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …

Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer

WH Lin, J Xiao, ZY Ye, DL Wei, XH Zhai, RH Xu… - Clinical …, 2021 - Springer
Abstract Background Circulating tumor DNA (ctDNA) is a promising diagnostic and
prognostic marker for many cancers and has been actively investigated in recent years …

Early detection of molecular residual disease and risk stratification for stage I to III colorectal cancer via circulating tumor DNA methylation

S Mo, L Ye, D Wang, L Han, S Zhou, H Wang… - JAMA …, 2023 - jamanetwork.com
Importance Detection of molecular residual disease and risk stratification as early as
possible may improve the treatment of patients with cancer. Efficient pragmatic tests are …

Combined genomic and epigenomic assessment of cell-free circulating tumor DNA (ctDNA) improves assay sensitivity in early-stage colorectal cancer (CRC)

ST Kim, VM Raymond, JO Park, E Zotenko, YS Park… - Cancer research, 2019 - AACR
Background: ctDNA has the potential to identify patients (pts) with early stage cancer;
however, current assays are challenged by limited sensitivity (~ 50%), reliance on a single …

Circulating tumour DNA for monitoring colorectal cancer—a prospective cohort study to assess relationship to tissue methylation, cancer characteristics and surgical …

EL Symonds, SK Pedersen, DH Murray, M Jedi… - Clinical …, 2018 - Springer
Background Cell-free circulating tumour-derived DNA (ctDNA) can be detected by testing for
methylated BCAT1 and IKZF1 DNA, which has proven sensitivity for colorectal cancer …

Circulating tumor DNA methylation biomarkers for characterization and determination of the cancer origin in malignant liver tumors

T Draškovič, N Zidar, N Hauptman - Cancers, 2023 - mdpi.com
Simple Summary Malignant liver tumors consist of primary tumors and metastases. A correct
diagnosis can be achieved with different methods; one of them is the analysis of the cell-free …

Early identification of treatment benefit by methylated circulating tumor DNA in metastatic colorectal cancer

CB Thomsen, TF Hansen… - … in medical oncology, 2020 - journals.sagepub.com
Background: The early identification of treatment effect is wanted in several settings,
including the management of metastatic colorectal cancer (mCRC). A potential universal …