The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis
Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …
there is considerable between-person variation in the rate of ageing and individual …
DNA methylation-based age clocks: From age prediction to age reversion
Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …
progressive decline in physiological functionality and enhanced disease vulnerability …
[HTML][HTML] DNA methylation-based measures of biological age: meta-analysis predicting time to death
Estimates of biological age based on DNA methylation patterns, often referred to as
“epigenetic age”,“DNAm age”, have been shown to be robust biomarkers of age in humans …
“epigenetic age”,“DNAm age”, have been shown to be robust biomarkers of age in humans …
Associations of age, sex, race/ethnicity, and education with 13 epigenetic clocks in a nationally representative US sample: the Health and Retirement Study
Background Many DNA methylation-based indicators have been developed as summary
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …
An epigenome-wide association study of sex-specific chronological ageing
Background Advanced age is associated with cognitive and physical decline and is a major
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …
Epigenetics of aging and aging-related disease
Aging is associated with a wide range of human disorders, including cancer, diabetes,
cardiovascular, and neurodegenerative diseases. Long thought to be an inexorable road …
cardiovascular, and neurodegenerative diseases. Long thought to be an inexorable road …
Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex
GL Shireby, JP Davies, PT Francis, J Burrage… - Brain, 2020 - academic.oup.com
Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …
as 'epigenetic clocks', which have been widely used to identify differences between …
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort
L Perna, Y Zhang, U Mons, B Holleczek, KU Saum… - Clinical …, 2016 - Springer
Background Previous studies have developed models predicting methylation age from DNA
methylation in blood and other tissues (epigenetic clock) and suggested the difference …
methylation in blood and other tissues (epigenetic clock) and suggested the difference …
Alcohol consumption and methylation-based measures of biological age
JK Kresovich, AM Martinez Lopez… - The Journals of …, 2021 - academic.oup.com
Epigenetic age acceleration is considered a measure of biological aging based on genome-
wide patterns of DNA methylation. Although age acceleration has been associated with the …
wide patterns of DNA methylation. Although age acceleration has been associated with the …
Universal DNA methylation age across mammalian tissues
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …