Normal ageing is associated with diverse physiological changes in all organ systems but the
rate and extent of these changes vary markedly among individuals. One aspect of ageing …

Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Age is the single greatest risk factor for a wide range of diseases, and as the mean age of
human populations grows steadily older, the impact of this risk factor grows as well …

Significance: Aging is a complex trait that is influenced by a combination of genetic and
environmental factors. Although many cellular and physiological changes have been …

The field of molecular epidemiology of aging involves the application of molecular methods
to measure aging processes and their genetic determinants in human cohorts. Over the last …

Age is the strongest risk factor for many diseases including neurodegenerative disorders,
coronary heart disease, type 2 diabetes and cancer. Due to increasing life expectancy and …

It is tempting to assume that a gradual accumulation of damage 'causes' an organism to age,
but other biological processes present during the lifespan, whether 'programmed'or …

Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

Organismal aging is driven by interconnected molecular changes encompassing internal
and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets …

Aging results in various deleterious changes in the human body that may lead to loss of
function and the manifestation of chronic diseases. While diseases can generally be reliably …