Proteomics and epidemiological models of human aging

C Ubaida-Mohien, R Moaddel, AZ Moore… - Frontiers in …, 2021 - frontiersin.org
Human aging is associated with a decline of physical and cognitive function and high
susceptibility to chronic diseases, which is influenced by genetics, epigenetics …

[HTML][HTML] Patterns of aging biomarkers, mortality, and damaging mutations illuminate the beginning of aging and causes of early-life mortality

ED Kinzina, DI Podolskiy, SE Dmitriev, VN Gladyshev - Cell reports, 2019 - cell.com
An increase in the probability of death has been a defining feature of aging, yet human
perinatal mortality starts high and decreases with age. Previous evolutionary models …

[HTML][HTML] Aging: a common driver of chronic diseases and a target for novel interventions

BK Kennedy, SL Berger, A Brunet, J Campisi… - Cell, 2014 - ncbi.nlm.nih.gov
Mammalian aging can be delayed with genetic, dietary and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …

[HTML][HTML] Geroscience: linking aging to chronic disease

BK Kennedy, SL Berger, A Brunet, J Campisi… - Cell, 2014 - cell.com
Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …

Molecular damage in aging

VN Gladyshev, SB Kritchevsky, SG Clarke, AM Cuervo… - Nature Aging, 2021 - nature.com
Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …

Computational biology for ageing

D Wieser, I Papatheodorou… - … Transactions of the …, 2011 - royalsocietypublishing.org
High-throughput genomic and proteomic technologies have generated a wealth of publicly
available data on ageing. Easy access to these data, and their computational analysis, is of …

Single-cell omics in ageing: a young and growing field

X He, S Memczak, J Qu, JCI Belmonte, GH Liu - Nature Metabolism, 2020 - nature.com
Organismal ageing results from interlinked molecular changes in multiple organs over time.
The study of ageing at the molecular level is complicated by varying decay characteristics …

Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

[PDF][PDF] Biomarkers of aging

RC Adelman - 1987 - deepblue.lib.umich.edu
What is meant by the phrase, biomarkers of aging? In my experience, this phrase has
different meanings to different people. Some regard it as a means to measure the degree of …

The new biology of ageing

L Partridge - … Transactions of the Royal Society B …, 2010 - royalsocietypublishing.org
Human life expectancy in developed countries has increased steadily for over 150 years,
through improvements in public health and lifestyle. More people are hence living long …