Coronaviruses encode multifunctional proteins that are critical for viral replication and for
blocking the innate immune response to viral infection. One such multifunctional domain is …

ABSTRACT Human coronavirus NL63 (HCoV-NL63), a common human respiratory
pathogen, is associated with both upper and lower respiratory tract disease in children and …

Infection by human coronaviruses is usually characterized by rampant viral replication and
severe immunopathology in host cells. Recently, the coronavirus papain-like proteases …

Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory
syndrome coronavirus (MERS-CoV) encode multifunctional papain-like proteases (PLPs) …

Coronavirus papain-like proteases (PLPs or PLpro), such as the one encoded in the
genome of the infectious Middle East Respiratory Syndrome (MERS) virus, have multiple …

Viruses have evolved elaborate mechanisms to evade or inactivate the complex system of
sensors and signaling molecules that make up the host innate immune response. Here we …

Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes a papain-like
protease (PLpro) with both deubiquitinating (DUB) and deISGylating activities that are …

The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV
PLpro) carries out N-terminal processing of the viral replicase polyprotein, and also exhibits …

Coronaviruses and arteriviruses, members of the order Nidovirales, are positive strand RNA
viruses that encode large replicase polyproteins that are processed by viral proteases to …

Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes
with protease activity to process the viral replicase polyprotein and deubiquitinating …