Recent advances in single-cell RNA-sequencing technology have enabled us to
characterize a variety of different cell types in each brain region. However, the evolutionary …

The human brain is composed of increasingly recognized heterogeneous cell types.
Applying single-cell genomics to brain tissue can elucidate relative cell type proportions as …

Modern RNA sequencing methods have greatly increased our understanding of the
molecular fingerprint of neurons, astrocytes and oligodendrocytes throughout the central …

Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …

The brain is the most complex tissue in terms of cell types that it comprises, to the extent that
it is still poorly understood. Single cell genome and transcriptome profiling allow to …

The mammalian brain is characterized by distinct classes of cells that differ in morphology,
structure, signaling, and function. Dysregulation of gene expression in these cell populations …

The cellular complexity of human brain development has been intensively investigated,
although a regional characterization of the entire human cerebral cortex based on single …

The brain is constituted of heterogeneous types of neuronal and non-neuronal cells, which
are organized into distinct anatomical regions, and show precise regulation of gene …

Biology has been facing a daunting problem since the cell was understood to be the
building block of metazoans: how do we study multicellular systems, when a universal …

Understanding brain function involves improved knowledge about how the genome
specifies such a large diversity of neuronal types. Transcriptome analysis of single neurons …